PrEP and PEP

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Pre-exposure prophylaxis (PrEP) is the use of antiretroviral medication to prevent acquisition of HIV infection; it consists of one pill taken once a day and is efficacious and easy to use. PrEP is an effective prevention strategy for reducing HIV acquisition risk by 90-99% if taken as prescribed and is recommended for men who have sex with men (MSM), people who inject drugs (PWID), transgender men and women, and heterosexual adults who are at high risk for HIV infection1.

Post-exposure prophylaxis (PEP) is the use of antiretroviral medication for 28 days to prevent acquisition of HIV after a possible sexual or injection drug use exposure. It must be started within 72 hours of the exposure.

The Denver PTC can assist with:

  • Clinic protocols for PrEP and PEP
  • Clinical consultation for patient management
  • Sexual risk assessment tools, resources for identifying eligible patients, and patient counseling tools
  • Training on the science and implementation of PrEP and PEP, as well as the counseling that should be offered in support of PrEP and PEP
  • Process documents and tools to assist with incorporating PrEP and PEP into your clinic’s flow
  • Pharmaceutical and pharmacy partnership guidance


1. Grant RM et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. New Engl Jour Med. 2010, 363(27):2587-2599.

HIV PrEP for the Primary Care Provider Video

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HIV pre-exposure prophylaxis (PrEP) is quickly becoming the standard of care for the prevention of HIV among persons at increased risk for acquiring the disease. HIV Pre-Exposure Prophylaxis (PrEP) for the Primary Care Provider, a short 15 minute video developed by the Denver Prevention Training Center in partnership with the National Association of Community Health Centers, demonstrates the PrEP initiation process including patient/provider interactions, patient eligibility and clinical guidance.

View video here.


 Supporting Documents Title

Denver Health PrEP Clinical Eligibility

Who Should Consider PrEP?

Denver Health PrEP Clinical Guide

DH PrEP Clinical Guide

Denver PTC PrEP Fact Sheet

PrEP Fact Sheet

Denver Public Health PrEP Fact Sheet

DPH PrEP Fact Sheet

Denver Public Health PEP Fact Sheet

DPH PEP Fact Sheet

Beyond the Basics: NACCHO Webinar

NACCHO Webinar

CDC PrEP Clinical Practice Guidelines

CDC PrEP Guidelines

CDC PrEP Clinical Providers Supplement

CDC PrEP Providers Supplement

CDC PrEP Fact Sheet

CDC PrEP Fact Sheet


Proud to be Prepped

PrEP Hotline

PrEP Provider Directory

Basic PrEP Q&As

How PrEP works in the Body (video)

NASTAD Billing Code Guide

PrEP Watch (materials clearinghouse)

HIV Risk Reduction Tool


Contact Us

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