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Pre-exposure prophylaxis (PrEP) is an effective prevention strategy for reducing HIV acquisition risk by 90-99% if taken as prescribed and is recommended for men who have sex with men (MSM), intravenous drug users (IDUs), transgender men and women, and heterosexual adults who are at high risk for HIV infection.1 PrEP is the use of antiretroviral medication to prevent acquisition of HIV infection; it consists of one pill taken once a day, and is efficacious and easy to use. At present, the only medication with an FDA-approved indication for PrEP is oral tenofovir-emtricitabine (TDF-FTC) which is available as a fixed-dose combination in a tablet called Truvada. Any licensed prescriber can prescribe PrEP. Primary care providers and settings should consider offering PrEP to patients at high-risk for HIV. PrEP is part of a comprehensive prevention plan that includes adherence and prevention counseling, HIV risk behavior counseling, HIV prevention education, and the provision of condoms.

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